Topics and Goals:
A disease pattern is a complex interplay of multiple factors that finally
results in a disorder of the entire organism. Correcting the function of
one particular target protein is usually the way to interfere with such a
disease situation and to subsequently cure by drug therapy. However, we
are facing a more complex picture. Interference with highly regulated and
multiply interlinked cellular networks occurs even when mainly addressing
one single protein. Systems biology tries to approach biology from an
integrative rather than a reductionist's point of view. As a consequence,
what can systems biology contribute to our field of drug research? Can we
expect important insights into the mode of action of drugs, particularly
with respect to polypharmacology? Nevertheless, in the planned workshop
we do not want to lose sight of molecular aspects of our field of
interest. Starting from atomic details of interactions, as captured by
quantum chemistry, we want to proceed to computational tools that support
the design and ranking of our design hypotheses. The meeting will also
cover latest developments in some special and well-established target
classes such as kinases or P450 enzymes. What can chemical biology
contribute to screening, target discovery and lead discovery? Such
techniques help to elucidate details in characterizing protein networks
in cells. How much can computational tools support the identification of
proteins that mutually talk to each other in signalling cascades? The
workshop is intended to address these and similar questions by expert
presentations and by fostering discussions among the attendees.
The workshop is organized by:
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