frame
frame  International Workshop 2014 - Rauischholzhausen frame
frame frame frame
frame
frame frame Marburg, 21. Sep. 2017 frame
frame
frame Announcement
frame
frame Program
frame
frame Location
frame
frame Accommodation
frame
frame Application
frame
frame Contact
frame
frame Practical Information
frame
frame Sponsors
frame
frame Archive
frame
frame  
frame
frame  
frame
frame AG Klebe



frame frame

Announcement






Topics and Goals:

The topic of the meeting aims at taking novel developments and challenges in our field of drug discovery into account. In the past, we considered and handled time-dependent processes in drug design rather superficially, also to keep things as simple and manageable as possible. However, experimental evidence collected in recent time clearly shows that the binding event and the desired pharmacological effect of drug action are time-dependent and that time matters significantly. The proteins, we are targeting, exist for different time-spans, the drug molecules bind with deviating interaction kinetics to their targets and their residence time on the target could be quite different from molecule to molecule. Even clinically such effects manifest with quite different drug efficacies. We therefore decided to put "The Aspect of Time in Drug Design" into the focus of our next workshop. How important are time-dependent processes for affinity, selectivity and efficacy of drug candidates? What is the current status of our understanding of temporal changes in interaction networks and what is the influence of local changes of concentrations with time? Methods are available to simulate time-dependent phenomena, but are they also suited and applicable to elucidate our problems? Can experimental techniques resolve the time-dependent steps in drug action? Proteins exist as potential drug targets only within a particular time window. Therefore, how does the evolution of targets impact our ability to address them with drugs over time? The workshop is intended to address these and similar questions by expert presentations and by fostering discussions among the attendees.


The workshop is organized by:


frame frame frame
frame