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Bertoletti, Nicole



Portrait of Bertoletti, Nicole

Institut/Firma Philipps-Universität Marburg, Fachbereich Pharmazie
Adresse Institut für Pharmazeutische Chemie, Marbacher Weg 6, 35032 Marburg
Telefon +49 6421 28 21359
Intern 21339
E-Mail bertolet'at'staff.uni-marburg.de
Arbeitsgebiet Research Subject

Structural characterization of 17ß-hydroxysteroid dehydrogenase type 14 and inhibitor structure optimization using the crystallization and computational technique.


Peer-reviewed Publication

Bertoletti N,* Braun F,* Lepage M, Möller G, Adamski J, Heine A, Klebe G, Marchais-Oberwinkler S. New Insights into Human 17beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor
J. Med. Chem 2016 59 (14), 6961–6967

• Braun F,* Bertoletti N,* Möller G, Adamski J, Steinmetzer T, Salah M, Abdelsamie A. S, van Koppen C. J, Heine A, Klebe G, Marchais-Oberwinkler S. First Structure-Activity Relationship of 17beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme
J. Med. Chem 2016 59 (23), pp 10719–10737
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*These authors contributed equally


Conference Talks

Bertoletti N, Braun F, Zara L, Metz A, Heine A, Klebe G, Marchais-Oberwinkler S. X-ray Crystallographic Fragment Screening and Hit Optimization 25th Annual Meeting of the German Crystallographic Society, March 27-30 2017, Karlsruhe, Germany (5 min oral presentation)


Conference Posters

Bertoletti N, Braun F, Zara L, Metz A, Heine A, Klebe G, Marchais-Oberwinkler S. X-ray Crystallographic Fragment Screening and Hit Optimization 25th Annual Meeting of the German Crystallographic Society, March 27-30 2017, Karlsruhe, Germany

Bertoletti N, Zara L, Metz A, Braun F, Heine A, Klebe G, Marchais-Oberwinkler S.
X-ray Crystallographic Fragment Screening for the Development of New h17beta-HSD14 Inhibitors

Eighth Joint BER II and BESSY II User Meeting, December 7-9 2016, Berlin, Germany

Bertoletti N, Zara L, Metz A, Heine A, Klebe G, Marchais-Oberwinkler S.
Structure and Fragment Based Lead Discovery for New Potential h17beta-HSD14 Inhibitor

DPhG Jahrestagung 2016 / Annual meeting, October 4-7 2016, Munich, Germany

Bertoletti N, Braun F, Lepage M, Möller G, Adamski J, Heine A, Klebe G, Marchais-Oberwinkler S.
Insight into the Structure of Human 17beta-Hydroxysteroid Dehydrogenase type 14

EFMC-ISMC 2016 XXIV EFMC International Symposium on Medicinal Chemistry, August 28 - September 1 2016 Manchester, UK

Bertoletti N, Braun F, Lepage M, Heine A, Klebe G, Marchais-Oberwinkler S. Structure of 17beta-Hydroxysteroid Dehydrogenase 14 with First-in-Class Inhibitors. (Poster prize)
Seventh Joint BER II and BESSY II User Meeting, December 9-10, 2015 in Berlin, Germany

Bertoletti N, Braun F, Lepage M, Möller G, Adamski J, Heine A, Klebe G, Marchais-Oberwinkler S. Structure characterization of 17beta-hydroxysteroid dehydrogenase Type 14 and identification of the first inhibitors.
DPhG Jahrestagung 2015 / Annual meeting, September 23-25, 2015 in Düsseldorf, Germany