Affinity information for ZMR_PDB1A4G
Chemical Name:
Zanamivir
Molecular Weight: 331.3
Affinity value IC50: 3 nM
Experimental Conditions
Method n.a.
Temperature n.a.
pH n.a.
Buffer n.a.
Reagents/Additives n.a.
Literature
Author Smith P. W. et al.
Journal/Source J. Med. Chem., 41, (1998), 787
Literature primary yes
Comment
The IC50 value is the mean of a triplicate measurement and refers to the specific subtype B/Beijing/1/87, which is the subtype in the crystal structure (Ref. J. Med. Chem. 41, 1998, 798 seems to report an average of all B subtypes, instead). - A Kd of 1. 4 nM is also reported, but the given reference seems not to be correct. - The assay is described in Woods J. M. et al., Antimicrob. Agents Chemother. 37 , 1993, 1473 (= ref. 8 of the paper cited above).